The active pharmaceutical ingredient is FDA-regulated, but the compounded formulation as a finished product has not gone through the FDA's new drug application process
Regional differences in environment, pharmacogenetic, lifestyle and dietary differences of the patients might affect their treatment responses
Riesenberg D, Schulz V, Knorre WA, Pohl HD, Korz D, Sanders EA, et al
Hence, acquisition or loss of a cysteine often causes retention of the mutated protein in the ER by thiol-mediated mechanisms (Anelli et al., 2015), with consequent loss or gain of function
Contrave: Nausea, constipation, headache, insomnia Increased blood pressure and heart rate Other effects: anxiety, dizziness, dry mouth, tremors, risk of seizures in susceptible individuals Serious risks: liver problems, severe allergic reactions, neuropsychiatric events, including mood changes or suicidal thoughts Wegovy: Gastrointestinal issues: nausea, vomiting, diarrhea, constipation, abdominal pain Other effects: fatigue, headache, dizziness (especially during dose escalation) Serious risks: pancreatitis, gallbladder disease, thyroid tumors in high-risk patients, increased heart rate Important: Neither medication is a cure for obesity